We share the VISION of INCUBATING SOLUTION INTEGRATORS, for ambitious young scientists and engineers to learn and make impacts beyond their own means through integrative cross-disciplinary learning and collaborations.
MISSION: Controlled regeneration of complex epithelial tissues (e.g. liver) for diseased or injured patients. We INTEGRATE (study, source, adapt, and assemble) technologies and knowledges into solutions for complex biomedical problems.
Research Goals:
Establish fundamental biomaterials and complex tissue-engineering principles to:
Understand meso-scale (nm-um) cellular dynamic processes in response to spatially- and temporally presented extra-cellular mechanical and chemical cues.
Precision engineering of micro- and nano-featured cellular niche (supporting cells, extra-cellular matrices, soluble factors, and shear/compression) for complex epithelial tissues.
Cross-scale (nm-mm) imaging and quantification of cellular niche for understanding and controlling tissue regeneration in living organisms.
Develop innovative solutions for biomedical applications:
Predictive in vitro drug and pathogen testing platforms.
Redefine pathology standards by quantiative imaging of molecular and cellular features.
Shared Values:
Respect : every LCTE member is uniquely important and yet can only thrive when consciously sensitive to other members and the collective impacts. Decisions incorporate inputs from all the stakeholders for fairness and transparency.
Professionalism: every LCTE member strives to attain ever higher quality and standard of her/his own work through mutual empowerment, critique and support to each other.
No-walls culture: solutions to real-life problems can never be confined within artificially-created boundaries (organizational, disciplinary, cultural, inter-personal, or mental inertia). |
News & Events:
Click here for new jobs or PhD scholarship openings!
Interface with reproductive biologists and drug testing industry - ILSI-HESI workshop on testicular toxicity models
Latest Awards:
Congratulations to Jeffrey for winning Best Poster Presentation Award at NUS-Kyushu-U Joint Symposium on Biochemistry and Cell Biology.
Congratulations to Dr. Dean Tai for successful launching of a spin-off company, Histoindex Pte Ltd, that has attracted major investment from various sources!
Latest Publications:
Deepak Choudhury and Ciprian Iliescu published a paper on developement of a multi-channel microfluidic perfusion platform for culturing zebrafish embryos and capturing live images of various tissues and organs inside the embryo. Fish and Chips: a microfluidic perfusion platform for monitoring zebrafish development. Lab on a Chip, in press. Available online on 7 December 2011.
Lei Xia, Rashidah Bte Sakban, Yinghua Qu, Xin Hong, Wenxia Zhang, Bramasta Nugraha, Wen Hao Tong, Abhishek Ananthanarayanan, and Rui Rui Jia published a paper on development of an improved hepatocyte 3D spheroid model on RGD and galactoseconjugated membranes and demostrated that cytochrome P450 induction by prototypical inducers was comparable or better than that observed with hepatocyte sandwich cultures, suggesting that this model can be an ideal alternative to 2D hepatocyte culture models for drug safety applications. Tethered spheroids as an in vitro hepatocyte model for drug safety screening. Biomaterials, in press. Available online 19 December 2011.
Bramasta Nugraha published a paper on the tissue-like cell culture configuration improve post-cryopreservation viability of primary rat hepatocytes as cell-to-cell contact is beneficial in the maintenance of viability post-cryopreservation and that the vitrification approach was far superior to those of conventional freezing when applied to 2D and 3D hepatocyte based engineered cultures. Influence of cell culture configuration on the post-cryopreservation viability of primary rat hepatocytes. Biomaterials, January 2012; 33(3): 829-836.
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